The human brain development is accomplished through dynamic and elaborate processes (Figure 1). Functional neural circuits are established by these exquisite processes during brain development and enable higher brain function such as learning, cognition and social behavior, which are essential for our life. A number of evidences have shown that brain development is mainly regulated by gene expression program including epigenetics.

Alterations of the gene expression program cause abnormalities of processes of brain development that lead to dysfunction of brain such as developmental disorders and psychiatric disorders.

However, mechanisms of the regulation of gene expression program that control brain development and function still remain largely unknown.

Our research group is tackling to elucidate the mechanisms of brain development and its disorders and to develop therapeutic avenues of the diseases by studying the regulatory mechanisms of gene expression program contributing brain development and function.

Section	Section of Nagoya Research Center for Brain & Neural Circuits
Group	Group of Brain Function and Development
Leader	Keita Tsujimura, Ph.D.
Contact	+81-052-789-2963 tsujimura.keita@e.mbox.nagoya-u.ac.jp
Links	Nagoya University, Group of Braon Function and Development